Free radicals and oxidative stress: Signaling mechanisms, redox basis for human diseases, and cell cycle regulation

IZ Sadiq - Current Molecular Medicine, 2023 - benthamdirect.com
Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Two faces of neutrophils in liver disease development and progression

Y Cho, G Szabo - Hepatology, 2021 - Wiley Online Library
Neutrophils, the most abundant type of leukocyte in human blood, play a major role in host
defense against invading pathogens and in sterile injury. Neutrophil infiltration is …

Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex

B Djahanschiri, G Di Venanzio, JS Distel… - PLoS …, 2022 - journals.plos.org
Nosocomial pathogens of the Acinetobacter calcoaceticus-baumannii (ACB) complex are a
cautionary example for the world-wide spread of multi-and pan-drug resistant bacteria …

Semi-refined carrageenan promotes generation of reactive oxygen species in leukocytes of rats upon oral exposure but not in vitro

AS Tkachenko, YG Kot, VA Kapustnik… - Wiener Medizinische …, 2021 - Springer
Aim To assess the ability of the common food additive E407a (semi-refined carrageenan) to
enter leukocytes in vitro and generate reactive oxygen species (ROS) in leukocytes as a …

[HTML][HTML] Clotting propensity of surface-treated membranes in a hemodialysis set-up that avoids systemic anticoagulation

H Kawanishi, M Koremoto, CFM Franssen… - Seminars in …, 2024 - Elsevier
The development of biocompatible membranes, aiming to limit the inflammatory response,
oxidative stress, and coagulability during hemodialysis, has been an important step in …

Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection

L Shaban, GT Nguyen, BD Mecsas-Faxon… - PLoS …, 2020 - journals.plos.org
Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject
6–7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine …

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

S Meier, JA Seddon, E Maasdorp, L Kleynhans… - PloS one, 2022 - journals.plos.org
Mycobacterium tuberculosis (M. tb) causes tuberculosis (TB) and remains one of the leading
causes of mortality due to an infectious pathogen. Host immune responses have been …

The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst

TL Westerman, L Bogomolnaya… - PloS one, 2018 - journals.plos.org
Neutrophils are innate immune response cells designed to kill invading microorganisms.
One of the mechanisms neutrophils use to kill bacteria is generation of damaging reactive …

Encapsulated Streptococcus suis impairs optimal neutrophil functions which are not rescued by priming with colony-stimulating factors

M Bleuzé, JP Lavoie, C Bédard, M Gottschalk… - Plos one, 2024 - journals.plos.org
The porcine pathogen and zoonotic agent Streptococcus suis induces an exacerbated
inflammation in the infected hosts that leads to sepsis, meningitis, and sudden death …