Traditional cancer treatments based on chemo-and/or radiotherapy effectively kill only
differentiated cancer cells, while metastasis and recurrences are caused by surviving cancer …

Pharmaceutical wastewater contamination via azithromycin antibiotic and the continuous
emergence of some strains of bacteria, cancer, and the Covid-19 virus. Azithromycin …

Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …

The resistance, plasticity and heterogeneity of cancer cells, including glioblastoma (GB)
cells, have prompted the investigation of various agents for possible adjuncts and …

The poor outcomes in glioblastoma (GBM) necessitate new treatments. As GBM is highly
vascularized and its growth is largely dependent on angiogenesis, angiogenesis inhibitors …

Solid tumors are predisposed to hypoxia, which induces tumor progression, and causes
resistance to treatment. Hypoxic tumor cells exploit auto-and mitophagy to facilitate …

Chronic myeloid leukemia (CML) is a hematologic disorder characterized by the oncogene
BCR-ABL1, which encodes an oncoprotein with tyrosine kinase activity. Imatinib, a BCR …

One of the most essential health problems is cancer, the first or second cause of death
worldwide. Head and neck cancers are hard to detect due to non-specific symptoms. The …

A large proportion of patients with chronic myeloid leukemia (CML; 20%–50%) develop
resistance to imatinib in a BCR-ABL1-independent manner. Therefore, new therapeutic …

Cancer persists as a significant global health challenge, claiming millions of lives annually
despite remarkable strides in therapeutic innovation. Challenges such as drug resistance …