[HTML][HTML] Distinct hepatocyte identities in liver homeostasis and regeneration

F Chen, K Schönberger, JS Tchorz - JHEP Reports, 2023 - Elsevier
The process of metabolic liver zonation is spontaneously established by assigning
distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical …

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

S Annunziato, T Sun, JS Tchorz - Hepatology, 2022 - Wiley Online Library
WNT/β‐catenin signaling plays pivotal roles during liver development, homeostasis, and
regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible …

Cellular plasticity at the nexus of development and disease

LB Spatz, RU Jin, JC Mills - Development, 2021 - journals.biologists.com
ABSTRACT In October 2020, the Keystone Symposia Global Health Series hosted a
Keystone eSymposia entitled 'Tissue Plasticity: Preservation and Alteration of Cellular …

Macrophage pathology in hepatotoxicity

J Yamate, T Izawa, M Kuwamura - Journal of Toxicologic Pathology, 2023 - jstage.jst.go.jp
The liver is the most important organ that metabolizes and detoxifies chemicals taken into
the body. Therefore, there is always a risk of liver damage owing to the toxic effects of …