Application of exosomes as liquid biopsy in clinical diagnosis

B Zhou, K Xu, X Zheng, T Chen, J Wang… - Signal transduction and …, 2020 - nature.com
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating
tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small …

[HTML][HTML] Regulation of exosome production and cargo sorting

H Wei, Q Chen, L Lin, C Sha, T Li, Y Liu… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Cellular communication can be mediated by the exchange of biological information, mainly
in the form of proteins and RNAs. This can occur when extracellular vesicles, such as …

Methodological guidelines to study extracellular vesicles

FAW Coumans, AR Brisson, EI Buzas… - Circulation …, 2017 - Am Heart Assoc
Owing to the relationship between extracellular vesicles (EVs) and physiological and
pathological conditions, the interest in EVs is exponentially growing. EVs hold high hopes …

Using exosomes, naturally-equipped nanocarriers, for drug delivery

EV Batrakova, MS Kim - Journal of Controlled Release, 2015 - Elsevier
Exosomes offer distinct advantages that uniquely position them as highly effective drug
carriers. Comprised of cellular membranes with multiple adhesive proteins on their surface …

Exosomes: new molecular targets of diseases

S Samanta, S Rajasingh, N Drosos, Z Zhou… - Acta Pharmacologica …, 2018 - nature.com
Extracellular vesicles (EVs) comprise apoptotic bodies, microvesicles and exosomes, and
they perform as key regulators in cell-to-cell communication in normal as well as diseased …

[HTML][HTML] ExtraPEG: a polyethylene glycol-based method for enrichment of extracellular vesicles

MA Rider, SN Hurwitz, DG Meckes - Scientific reports, 2016 - nature.com
Initially thought to be a means for cells to eliminate waste, secreted extracellular vesicles,
known as exosomes, are now understood to mediate numerous healthy and pathological …

A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

I Helwa, J Cai, MD Drewry, A Zimmerman, MB Dinkins… - PloS one, 2017 - journals.plos.org
Exosomes play a role in cell-to-cell signaling and serve as possible biomarkers. Isolating
exosomes with reliable quality and substantial concentration is a major challenge. Our …

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

B Liu, BW Lee, K Nakanishi, A Villasante… - Nature biomedical …, 2018 - nature.com
The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has
recently been exploited for the treatment of diseases. For example, EVs secreted by …

[HTML][HTML] Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

C Wang, Z Li, Y Liu, L Yuan - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry
many macromolecules from their parental cells and play important roles in intercellular …

[HTML][HTML] Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction

K Lv, Q Li, L Zhang, Y Wang, Z Zhong, J Zhao, X Lin… - Theranostics, 2019 - ncbi.nlm.nih.gov
Bone marrow mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs)
have been widely used for treating myocardial infarction (MI). However, low retention and …