Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …

Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric
diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety …

Anxiety-like behaviors in mice include social avoidance and avoidance of bright spaces.
Whether these features are distinctly regulated is unclear. We demonstrate that in mice …

This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

In this article, we highlight the importance of dynamic reorganization of neural circuitry
during adolescence, as it relates to the development of emotion reactivity and regulation. We …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

The basolateral amygdala (BLA) mediates associative learning for both fear and reward.
Accumulating evidence supports the notion that different BLA projections distinctly alter …

Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse
behavioural functions,; however, the precise circuit computations remain unknown. One …