Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Abstract Background Quantitative PCR (qPCR) aims to measure the DNA or RNA
concentration in diagnostic and biological samples based on the quantification cycle (Cq) …

Cardiac ischemia leads to the loss of myocardial tissue and the activation of a repair process
that culminates in the formation of a scar whose structural characteristics dictate propensity …

Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling
process associated with different types of fibrosis. Recent studies have shown that …

Induced pluripotent stem cell (iPS) reprogramming allows to turn a differentiated somatic cell
into a pluripotent cell. This process is accompanied by many changes in fundamental cell …

Rationale: Circumstantial evidence links the development of heart failure to posttranslational
modifications of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless …

Disease-associated genetic variants that lie in non-coding regions found by genome-wide
association studies are thought to alter the functionality of transcription regulatory elements …

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the
activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or …

Rationale: ANP (atrial natriuretic peptide) and BNP (B-type natriuretic peptide), encoded by
the clustered genes Nppa and Nppb, are important prognostic, diagnostic, and therapeutic …

Background The molecular mechanisms mediating postnatal loss of cardiac regeneration in
mammals are not fully understood. We aimed to provide an integrated resource of mRNA …