Highlights•Elucidation of the intricate mechanism involved in the pathogenesis of
rheumatoid arthritis.•Combination delivery in clinical trials and preclinical models.•Topical …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Nanoemulgel (NEG) pharmaceutical formulations are gaining popularity because of their
ability to serve both as a nanoemulsion and as a gel. These products are well-known for …

Novel delivery systems for cosmetics, drugs, and food ingredients are of great scientific and
industrial interest due to their ability to incorporate and protect active substances, thus …

Essential oils (EOs) are concentrated, hydrophobic volatile compounds derived from
different parts of plants. They are recognized for their diverse and versatile functional …

The current study aimed to develop a topical emulgel of dasatinib (DTB) for rheumatoid
arthritis (RA) treatment to reduce systemic side effects. The quality by design (QbD) …

Topical and transdermal drug delivery are advantageous administration routes, especially
when treating diseases and conditions with a skin etiology. Nevertheless, conventional …

Nanoemulsions and bigels are biphasic delivery systems that can be used for topical
applications. The aim of this study was to incorporate an oil-in-water ciprofloxacin …

Transdermal drug delivery systems are skin through drug delivery systems. They offer
several advantages over conventional oral and parenteral routes, such as improved patient …

The anti-inflammatory drugs that are generally available possess the disadvantage of
hydrophobicity, which leads to poor permeability and erratic bioavailability. Nanoemulgels …