Electrically stimulated 3D bioprinting of gelatin-polypyrrole hydrogel with dynamic semi-IPN network induces osteogenesis via collective signaling and …

SD Dutta, K Ganguly, A Randhawa, TV Patil, DK Patel… - Biomaterials, 2023 - Elsevier
In recent years, three-dimensional (3D) bioprinting of conductive hydrogels has made
significant progress in the fabrication of high-resolution biomimetic structures with gradual …

[HTML][HTML] Silk-based hydrogel incorporated with metal-organic framework nanozymes for enhanced osteochondral regeneration

Z Cao, H Wang, J Chen, Y Zhang, Q Mo, P Zhang… - Bioactive Materials, 2023 - Elsevier
Osteochondral defects (OCD) cannot be efficiently repaired due to the unique physical
architecture and the pathological microenvironment including enhanced oxidative stress …

Genetic delivery and gene therapy in pulmonary hypertension

N Rai, M Shihan, W Seeger, RT Schermuly… - International Journal of …, 2021 - mdpi.com
Pulmonary hypertension (PH) is a progressive complex fatal disease of multiple etiologies.
Hyperproliferation and resistance to apoptosis of vascular cells of intimal, medial, and …

Developmental and functional heterogeneity of white adipocytes within a single fat depot

KY Lee, Q Luong, R Sharma, JM Dreyfuss… - The EMBO …, 2019 - embopress.org
Recent studies suggest that, even within a single adipose depot, there may be distinct
subpopulations of adipocytes. To investigate this cellular heterogeneity, we have developed …

[HTML][HTML] Cartilage oligomeric matrix protein promotes epithelial-mesenchymal transition by interacting with transgelin in colorectal cancer

W Zhong, H Hou, T Liu, S Su, X Xi, Y Liao, R Xie… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background and Purpose: The role of the cartilage oligomeric matrix protein (COMP) in
epithelial-mesenchymal transition (EMT) in tumor progression has been studied, but its …

Evolution and function of calponin and transgelin

TB Hsieh, JP Jin - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Calponin and transgelin (originally named SM22) are homologous cytoskeleton proteins
that regulate actin-activated myosin motor functions in smooth muscle contraction and non …

Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms

MJ Shannon, GL McNeill, B Koksal, J Baltayeva… - Developmental Cell, 2024 - cell.com
Human trophoblast stem cells (hTSCs) and related trophoblast organoids are state-of-the-art
culture systems that facilitate the study of trophoblast development and human placentation …

Alterations in the global proteome and phosphoproteome in third generation EGFR TKI resistance reveal drug targets to circumvent resistance

X Zhang, TK Maity, KE Ross, Y Qi, CM Cultraro… - Cancer research, 2021 - AACR
Lung cancer is the leading cause of cancer mortality worldwide. The treatment of patients
with lung cancer harboring mutant EGFR with orally administered EGFR tyrosine kinase …

TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formation

Z Chen, S He, Y Zhan, A He, D Fang, Y Gong, X Li… - …, 2019 - thelancet.com
Background Metastatic bladder cancer (BLCA) is a lethal disease with an unmet need for
study. Transgelin (TAGLN) is an actin-binding protein that affects the dynamics of the actin …

[HTML][HTML] Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress

IM Saadeldin, AAA Swelum, M Elsafadi… - Journal of advanced …, 2020 - Elsevier
The Arabian camel is the largest known mammal that can survive in severe hot climatic
conditions. We provide the molecular explanation for the thermotolerance of camel …