Embryonic cells grow in environments that provide a plethora of physical cues, including
mechanical forces that shape the development of the entire embryo. Despite their …

Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …

The current methods of generating human cerebral organoids rely excessively on the use of
Matrigel or other external extracellular matrices (ECM) for cell micro-environmental …

Embryoids and organoids hold great promise for human biology and medicine. Herein, we
discuss conceptual and technological frameworks useful for developing high-fidelity …

Research in developmental biology has been recently enriched by a multitude of in vitro
models recapitulating key milestones of mammalian embryogenesis. These models obviate …

Increased control of biological growth and form is an essential gateway to transformative
medical advances. Repairing of birth defects, restoring lost or damaged organs, normalizing …

Multicellular organisms of various complexities self-organize in nature. Organoids are in
vitro 3D structures that display important aspects of the anatomy and physiology of their in …

There is no doubt that the development of transplantable synthetic kidneys could improve
the outcome for the many millions of people worldwide suffering from chronic kidney …

Decades of research have not yet fully explained the mechanisms of epithelial self-
organization and 3D packing. Single-cell analysis of large 3D epithelial libraries is crucial for …

During development, a single cell is transformed into a highly complex organism through
progressive cell division, specification and rearrangement. An important prerequisite for the …