Increasing evidence suggests that renal inflammation contributes to the pathogenesis and
progression of diabetic kidney disease (DKD) and that anti-inflammatory therapies might …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Fibrosis is the final common pathway of inflammatory diseases in various organs. The
inflammasomes play an important role in the progression of fibrosis as innate immune …

Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …

Abstract NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein
(TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …