[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning?

C Jung, D Kmiec, L Koepke, F Zech, T Jacob… - Journal of …, 2022 - Am Soc Microbiol
Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show …

SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines

S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …

An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease

Y Peng, SL Felce, D Dong, F Penkava, AJ Mentzer… - Nature …, 2022 - nature.com
Abstract NP105–113-B* 07: 02-specific CD8+ T cell responses are considered among the
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

C Riou, R Keeton, T Moyo-Gwete… - Science translational …, 2021 - science.org
SARS-CoV-2 variants that escape neutralization and potentially affect vaccine efficacy have
emerged. T cell responses play a role in protection from reinfection and severe disease, but …

Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19

J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …

In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms

S Cankat, MU Demael, L Swadling - Cellular & molecular immunology, 2024 - nature.com
Members of the coronaviridae family are endemic to human populations and have caused
several epidemics and pandemics in recent history. In this review, we will discuss the …

[HTML][HTML] Evolutionary analysis of Omicron variant BF. 7 and BA. 5.2 pandemic in China

Y Sun, M Wang, W Lin, W Dong, J Xu - Journal of Biosafety and Biosecurity, 2023 - Elsevier
Abstract On December 7, 2022, China adjusted public health control measures, there have
been widespread of SARS-CoV-2 infections in Chinese mainland. As the number of infected …

Using big sequencing data to identify chronic SARS-Coronavirus-2 infections

S Harari, D Miller, S Fleishon, D Burstein… - Nature …, 2024 - nature.com
The evolution of SARS-Coronavirus-2 (SARS-CoV-2) has been characterized by the
periodic emergence of highly divergent variants. One leading hypothesis suggests these …