Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

Respiratory‐induced changes in the partial pressures of arterial carbon dioxide and oxygen
play a major role in cerebral blood flow (CBF) regulation. Elevations in (hypercapnia) lead to …

The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

Study objective: To examine the effect of dexmedetomidine on CBF in critical ill patients with
or without TBI. Research design: Prospective controlled trial (ISRCTN57998533). Methods …

Background/aim: Sepsis-associated encephalopathy (SAE) is a severe complication of
sepsis that affects upwards of half of all sepsis patients. Few studies have examined the …

This study examined cerebral blood flow (CBF) and its regulation before and after a short-
term periodized aerobic exercise training intervention in patients with chronic obstructive …

The brain is a vital organ that relies on a constant and adequate blood flow to match oxygen
and glucose delivery with the local metabolic demands of active neurons. Thus exquisite …

Recent studies have shown that muscle alterations cannot totally explain peripheral muscle
weakness in COPD. Cerebral abnormalities in COPD are well documented but have never …

Alzheimer's disease (AD) is thought to be the most common cause of late-life dementia. But
pure AD is infrequent whereas AD pathology is often insufficient to explain dementia in the …

Cerebrovascular regulation is critically dependent upon the arterial partial pressure of
carbon dioxide (P aC O 2 P_aCO_2), owing to its effect on cerebral blood flow, tissue PCO 2 …