The view that substance addiction is a brain disease, although widely accepted in the
neuroscience community, has become subject to acerbic criticism in recent years. These …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Objective To compare the risk for all cause and overdose mortality in people with opioid
dependence during and after substitution treatment with methadone or buprenorphine and …

Objective Virtual reality (VR) is an exciting new technology with almost endless possible
uses in medicine. One area it has shown promise is pain management. This selective review …

Description: In May 2022, leadership within the US Department of Veterans Affairs (VA) and
US Department of Defense (DoD) approved a joint clinical practice guideline for the use of …

Objective This paper presents a systematic review and meta-analysis of available evidence
on remission rates for substance use disorders (SUDs), providing weighted mean estimates …

Objectives: Elevated mortality has been observed among individuals with opioid use
disorder (OUD) treated in addiction specialty clinics or programs. Information about OUD …

Purpose To examine the prevalence of comorbid chronic pain among patients with opioid
use disorder (OUD) and to compare other comorbidities (substance use disorder (SUD) …

Aims To compare long‐term outcomes among participants randomized to buprenorphine or
methadone. Design, Setting and Participants Follow‐up was conducted in 2011–14 of 1080 …

Your speech in the East Room of the White House, along with the remarks of the First Lady,
made it clear to the country that fighting this epidemic is a top priority of your Administration …