Differentiated status, low regenerative capacity and complex signaling make neuronal
tissues highly susceptible to translating an imbalance in cell homeostasis into cell death …

Cancers and neurological disorders are two major types of diseases. We previously
developed a new concept termed “Aberrant Cell Cycle Diseases”(ACCD), revealing that …

Background Ischemia can induce rapid activation of microglia in the brain. As key
immunocompetent cells, reactive microglia play an important role in pathological …

Background Microglial activation-mediated neuroinflammation is a major contributor to early
brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the …

Trimethylamine‐N‐oxide (TMAO), an intestinal flora metabolite of choline, may aggravate
atherosclerosis by inducing a chronic inflammatory response and thereby promoting the …

Alzheimer's disease (AD) is characterized by progressive memory loss and dementia. The
strong correlation between cognitive decline and the loss of synapses supports the idea that …

Background Intracerebral hemorrhage (ICH) has a high morbidity and mortality. The
peripheral immune system and cross-talk between peripheral blood and brain have been …

Failed communication between mitochondria and lysosomes causes dysfunctional
mitochondria, which may induce mitochondria-related neurodegenerative diseases. Here …

Background Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood
vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal …

Background Alzheimer's disease (AD) is a major clinical problem, but there is a distinct lack
of effective therapeutic drugs for this disease. We investigated the potential therapeutic …