Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …

Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Background: Human reproduction is regulated by the combined action of the follicle-
stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Although FSH …

Follicle-stimulating hormone signaling is essential for the initiation and early stages of
spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli …

FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with
its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role …

Background Spermatogenesis is a complex process that is controlled by interactions
between germ cells and somatic cells. The commitment of undifferentiated spermatogonia to …

Follicle-stimulating hormone (FSH) is a central regulator of male and female reproductive
function. Over the last decade, there has been a growing perception of the complexity …

Follicle stimulating hormone (FSH) and its receptor (FSHR) have been reported to be
responsible for several physiological functions and cancers. The responsiveness of stem …