The GTEx Consortium atlas of genetic regulatory effects across human tissues
GTEx Consortium - Science, 2020 - science.org
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …
effects on the transcriptome across human tissues and to link these regulatory mechanisms …
PhenomeXcan: Mapping the genome to the phenome through the transcriptome
Large-scale genomic and transcriptomic initiatives offer unprecedented insight into complex
traits, but clinical translation remains limited by variant-level associations without biological …
traits, but clinical translation remains limited by variant-level associations without biological …
[HTML][HTML] Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
Integrating results from genome-wide association studies (GWASs) and gene expression
studies through transcriptome-wide association study (TWAS) has the potential to shed light …
studies through transcriptome-wide association study (TWAS) has the potential to shed light …
Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics
Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a
wide range of traits using summary statistics from genome-wide association studies …
wide range of traits using summary statistics from genome-wide association studies …
Cross-disorder analysis of schizophrenia and 19 immune-mediated diseases identifies shared genetic risk
JG Pouget… - Human Molecular …, 2019 - academic.oup.com
Many immune diseases occur at different rates among people with schizophrenia compared
to the general population. Here, we evaluated whether this phenomenon might be explained …
to the general population. Here, we evaluated whether this phenomenon might be explained …
[HTML][HTML] Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Mendelian Randomisation (MR) is an increasingly popular approach that estimates the
causal effect of risk factors on complex human traits. While it has seen several extensions …
causal effect of risk factors on complex human traits. While it has seen several extensions …
Association of economic status and educational attainment with posttraumatic stress disorder: a Mendelian randomization study
Importance There is a well-established negative association of educational attainment (EA)
and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the …
and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the …
Detecting shared genetic architecture among multiple phenotypes by hierarchical clustering of gene-level association statistics
McGuirl et al. present a new method, Ward clustering to identify Internal Node branch length
outliers using Gene Scores (WINGS), for identifying shared genetic architecture among …
outliers using Gene Scores (WINGS), for identifying shared genetic architecture among …
[PDF][PDF] MR-APSS: a unified approach to Mendelian Randomization accounting for pleiotropy and sample structure using genome-wide summary statistics
Inferring the causal relationship between a risk factor (exposure) and a phenotype of interest
14 (outcome) is essential in biomedical research and social science [1]. Although …
14 (outcome) is essential in biomedical research and social science [1]. Although …
Coding and regulatory variants affect serum protein levels and common disease
V Emilsson, V Gudmundsdottir, A Gudjonsson… - bioRxiv, 2020 - biorxiv.org
Circulating proteins are prognostic for human outcomes including cancer, heart failure, brain
trauma and brain amyloid plaque burden. A deep serum proteome survey recently revealed …
trauma and brain amyloid plaque burden. A deep serum proteome survey recently revealed …