Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

Background Bronchiolitis is not only the leading cause of hospitalisation in US infants but
also a major risk factor for asthma development. Growing evidence supports clinical …

Microbial communities at the airway mucosal barrier are conserved and highly ordered, in
likelihood reflecting co-evolution with human host factors. Freed of selection to digest …

Recombination enhances the adaptive potential of organisms by allowing genetic variants to
be tested on multiple genomic backgrounds. Its distribution in the genome can provide …

Tracking bacterial evolution during chronic infection provides insights into how host
selection pressures shape bacterial genomes. The human-restricted opportunistic pathogen …

Heme is an indispensable cofactor for almost all aerobic life, including the human host and
many bacterial pathogens. During infection, heme and hemoproteins are the largest source …

Nontypable Haemophilus influenzae (NTHi) has emerged as an important opportunistic
pathogen causing infection in adults suffering obstructive lung diseases. Existing evidence …

The f erric u ptake r egulator (Fur) protein has been shown to function as a repressor of
transcription in a number of diverse microorganisms. However, recent studies have …

The ectopic gut colonization by orally derived pathobionts has been implicated in the
pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease …