Interconnections between circadian clocks and metabolism
Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …
environment; they are believed to be regulated by the core circadian clock interlocking …
[HTML][HTML] Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis
JYL Chiang, JM Ferrell - Liver research, 2020 - Elsevier
Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand
T-helper cells that produce interleukin-17 (TH17 cells) are a recently identified CD4+ T-cell
subset with characterized pathological roles in autoimmune diseases,,. The nuclear …
subset with characterized pathological roles in autoimmune diseases,,. The nuclear …
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism
AM Jetten - Nuclear receptor signaling, 2009 - journals.sagepub.com
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Transcriptional control of circadian rhythms and metabolism: a matter of time and space
All biological processes, living organisms, and ecosystems have evolved with the Sun that
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …
confers a 24-hour periodicity to life on Earth. Circadian rhythms arose from evolutionary …
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
JH Lee, T Wada, M Febbraio, J He, T Matsubara… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The aryl hydrocarbon receptor (AhR) also known as the dioxin
receptor or xenobiotic receptor is a member of the basic helix-loop-helix/period AhR nuclear …
receptor or xenobiotic receptor is a member of the basic helix-loop-helix/period AhR nuclear …
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons
TLR-mediated induction of cholesterol 25-hydoxylase transcription in dendritic cells and
macrophages is dependent on IFN-α/IFN-β and signaling through INF-αR and STAT1. The …
macrophages is dependent on IFN-α/IFN-β and signaling through INF-αR and STAT1. The …
Action of RORs and their ligands in (patho) physiology
LA Solt, TP Burris - Trends in Endocrinology & Metabolism, 2012 - cell.com
The retinoic-acid-receptor-related orphan receptors (RORs) are members of the nuclear
receptor (NR) superfamily whose activity has been implicated in several physiological and …
receptor (NR) superfamily whose activity has been implicated in several physiological and …
[HTML][HTML] Retinoic acid-related orphan receptors (RORs): regulatory functions in immunity, development, circadian rhythm, and metabolism
DN Cook, HS Kang, AM Jetten - Nuclear receptor research, 2015 - ncbi.nlm.nih.gov
In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …