The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

Summary RNA polymerase II (RNAPII) controls expression of all protein-coding genes and
most noncoding loci in higher eukaryotes. Calibrating RNAPII activity requires an assortment …

The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal
region of genes. Previous work has shed light on how Integrator binds to the paused …

Integrator is a multi-subunit protein complex responsible for premature transcription
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …

Spliceosomal small nuclear RNAs (snRNAs) are a fundamental class of non‐coding small
RNAs abundant in the nucleoplasm of eukaryotic cells, playing a crucial role in splicing …

The water flea Daphnia OF Müller 1776 (Crustacea: Cladocera) is an important model of
recent evolutionary biology. Here, we report a complete genome of Daphnia (Ctenodaphnia) …

The metazoan-specific Integrator complex catalyzes 3′ end processing of small nuclear
RNAs (snRNAs) and premature termination that attenuates the transcription of many protein …

Various genetic diseases associated with microcephaly and developmental defects are due
to pathogenic variants in the U4atac small nuclear RNA (snRNA), a component of the minor …

Systematic functional profiling of the gene set that directs embryonic development is an
important challenge. To tackle this challenge, we used 4D imaging of C. elegans …

Hepatic adipogenesis has common mechanisms with adipocyte differentiation such as
PPARγ involvement and the induction of adipose tissue-specific molecules. A previous …