Childhood immune thrombocytopenia (ITP) is a rare autoimmune bleeding disorder. Most
children recover within 6 to 12 months, but individual course is difficult to predict. We …

The most important reasons cited by the opponents of vaccines are concerns about vaccine
safety. Unlike issues such as autism for which no indisputable documentation of direct …

Autoimmune diseases with hematological manifestations are often characterized by
chronicity and relapses despite treatment, and the underlying pathogenetic mechanisms …

Immune thrombocytopenia (ITP) is an autoimmune disorder that causes a significant
reduction in peripheral blood platelet count. Fortunately, due to an increased understanding …

Background Interindividual genetic variations of human DNA methyltransferases (DNMTs),
which involve the methyl donor from the folate-related one-carbon metabolism pathway, are …

Hepatocellular carcinoma (HCC) is one of the most common solid tumors worldwide.
Epigenetic changes in gene expression, including DNA methylation and histone …

Abstract Tatton-Brown-Rahman syndrome (TBRS) is characterized by overgrowth, cognitive
deficiency, and distinctive facial features resulting from germline DNMT3A variants. This …

Background: DNA methylation is an epigenetic process that refers to chromatin-based
mechanisms in the regulation of gene expression without DNA alternation. It is mediated by …

DNMT3B plays a crucial role in the generation of aberrant methylation during
carcinogenesis. Polymorphisms in the DNMT3B gene may influence the DNA methylation …

Objective: The main aim of the present study was to determine the clinical significance of the
DNA methyltransferase 3B (DNMT3B) gene–579 G> T polymorphism in colorectal cancer …