The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region …

Epigenetics indicates that certain phenotypes of an organism can undergo heritable
changes in the absence of changes in the genetic DNA sequence. Many studies have …

Silicosis is a progressive inflammatory disease with poorly defined mechanisms and limited
therapeutic options. Recent studies found that microRNAs (miRNAs) and circular RNAs …

Abstract Background N 6-methyladenosine (m6A) is the most common and abundant
internal modification of RNA. Its critical functions in multiple physiological and pathological …

Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic
option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein …

Forkhead box (FOX) proteins are a wing-like helix family of transcription factors in the DNA-
binding region. By mediating the activation and inhibition of transcription and interactions …

Oral submucous fibrosis (OSF) is a precancerous condition in the oral cavity, which is
closely related to the myofibroblast conversion of buccal mucosal fibroblasts (BMFs) after …

Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular
disorders, such as coronary heart disorder, hypertension, and cardiomyopathy. Cardiac …

Methods Our WGS comprised 190 AAs with SPF with confirmed Scadding stage 4 on chest
X-ray and 770 AAs with sarcoidosis with Scadding stages 1, 2, and 3 (non-SPF). The variant …

Background Pulmonary fibrosis is a growing clinical problem that develops as a result of
abnormal wound healing, leading to breathlessness, pulmonary dysfunction and ultimately …