The insulin-like growth factor (IGF) axis plays important roles in cancer development and
metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long …

Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most
malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for …

RNA interference (RNAi) has been emerged as an effective method to silence a particular
gene utilizing a sequence‐specific mechanism for gene regulation. It induces target mRNA …

Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic
signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the …

Recently, nucleic acid drugs have been considered as promising candidates in treatment of
various diseases, especially cancer. Because of developing resistance to conventional …

Melatonin (MEL) is a pleiotropic neurohormone of increasing interest as a neuroprotective
agent in ocular diseases. Improving the mucoadhesiveness is a proposed strategy to …

Background Colorectal cancer (CRC) is the second leading cause of cancer death. Although
Regorafenib showed survival benefits in patients with CRC, reports imply the recurrence of …

In this review, we will discuss the current status of extracellular vesicle (EV) delivery via
biopolymeric scaffolds for therapeutic applications and the challenges associated with the …

Low uptake efficiency in vivo as well as systemic toxicities of nucleic‐acid nanovehicles
substantially retard the clinical translation of gene therapy. Targeted gene delivery to …

Breast cancer is the most common cause of cancer mortality in Western nations, with a
terrible prognosis. Many studies show that siRNA plays a role in the development of tumors …