Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range
of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations …

Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases …

The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …

Since their discovery in the 1960s, the family of Fe (II)/2-oxoglutarate-dependent
oxygenases has undergone a tremendous expansion to include enzymes catalyzing a vast …

Protein synthesis by the ribosome is highly dependent on the ionic conditions in the cellular
environment, but the roles of ribosome solvation have remained poorly understood …

The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-
oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesis …

The ribosome is a complex ribonucleoprotein-based molecular machine that orchestrates
protein synthesis in the cell. Both ribosomal RNA and ribosomal proteins can be chemically …

2-Oxoglutarate (2OG) and Fe (II)-dependent oxygenase domain-containing protein 1
(OGFOD1) is predicted to be a conserved 2OG oxygenase, the catalytic domain of which is …

The mechanisms by which gene expression is regulated by oxygen are of considerable
interest from basic science and therapeutic perspectives. Using mass spectrometric …