The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily
through the action of cytosolic phospholipase A2-α. Three major downstream pathways …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

Background Head and neck squamous cell carcinoma (HNSCC) is the six leading cancer by
incidence worldwide. The 5-year survival rate of HNSCC patients remains less than 65 …

Background Lung cancer has high morbidity and mortality across the globe, and lung
adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid …

Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important
paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have …

Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex
hormone that not only promotes the development of female secondary sexual …

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid (AA) into biologically
active epoxyeicosatrienoic acids (EETs), forming a pivotal metabolic pathway (AA-CYP …

Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism
of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three …