CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …
Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy?
CA Sabin - BMC medicine, 2013 - Springer
There is evidence that the life expectancy (LE) of individuals infected with the human
immunodeficiency virus (HIV) has increased since the introduction of combination …
immunodeficiency virus (HIV) has increased since the introduction of combination …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
HIV-1 DNA predicts disease progression and post-treatment virological control
JP Williams, J Hurst, W Stöhr, N Robinson, H Brown… - elife, 2014 - elifesciences.org
In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite
antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might …
antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might …
Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells
Initiation of antiretroviral therapy during the earliest stages of HIV-1 infection may limit the
seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviral treatment …
seeding of a long-lasting viral reservoir, but long-term effects of early antiretroviral treatment …
Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) …
Background Interim results from the children with HIV early antiretroviral (CHER) trial
showed that early antiretroviral therapy (ART) was life-saving for infants infected with HIV. In …
showed that early antiretroviral therapy (ART) was life-saving for infants infected with HIV. In …
Exhaustion of activated CD8 T cells predicts disease progression in primary HIV-1 infection
M Hoffmann, N Pantazis, GE Martin, S Hickling… - PLoS …, 2016 - journals.plos.org
The rate at which HIV-1 infected individuals progress to AIDS is highly variable and
impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 …
impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 …
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption
J Hurst, M Hoffmann, M Pace, JP Williams… - Nature …, 2015 - nature.com
Abstract Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following
transmission may induce a state of 'post-treatment control'(PTC) in some patients, in whom …
transmission may induce a state of 'post-treatment control'(PTC) in some patients, in whom …
Rapid initiation of antiretroviral therapy at HIV diagnosis: definition, process, knowledge gaps
Initiating antiretroviral therapy (ART) as early as the day of HIV diagnosis is a strategy of
increasing global interest to control the HIV epidemic and optimize the health of people …
increasing global interest to control the HIV epidemic and optimize the health of people …
Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
SE Rutstein, J Ananworanich, S Fidler… - African Journal of …, 2017 - journals.lww.com
Methods We conducted a scoping review [28] synthesizing the most recent literature on
clinical and public health implications of widespread AHI detection and treatment. This …
clinical and public health implications of widespread AHI detection and treatment. This …