The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Pathological vascular wall remodeling refers to the structural and functional changes of the
vessel wall that occur in response to injury that eventually leads to cardiovascular disease …

Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

Atherosclerosis is a chronic progressive inflammatory process that can eventually lead to
cardiovascular disease (CVD). Despite available treatment, the prevalence of …

Rationale: Hyperglycemic memory may explain why intensive glucose control has failed to
improve cardiovascular outcomes in patients with diabetes. Indeed, hyperglycemia …

Blood vessels are composed of two primary cell types, endothelial cells and smooth muscle
cells, each providing a unique contribution to vessel function. Signaling between these two …

Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression
has been widely demonstrated to occur in various types of cancer. Overexpression of …

Sirtuin1 (SIRT1), which belongs to a highly conserved family of protein deacetylase, is one
of the best-studied sirtuins. SIRT1 is involved in a variety of biological processes, including …

A three-dimensional microengineered human coronary artery–on–a–chip was developed for
investigation of the mechanism by which low and oscillatory shear stress (OSS) induces pro …

Monocytes/macrophages and vascular smooth muscle cells (vSMCs) are the main cell types
implicated in atherosclerosis development, and unlike other mature cell types, both retain a …