Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in shaping antitumour immune responses. In tumour …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

Unique Molecular Identifiers (UMIs) are random oligonucleotide barcodes that are
increasingly used in high-throughput sequencing experiments. Through a UMI, identical …

Developing therapeutic antibodies is laborious and costly. Here we report a method for
antibody discovery that leverages the Illumina HiSeq platform to, within 3 days, screen in the …

Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Antibody memory protects humans from many diseases. Protective antibody memory
responses require activation of transcriptional programs, cell proliferation, and production of …

Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …

Driven by dramatic technological improvements, large-scale characterization of lymphocyte
receptor repertoires via high-throughput sequencing is now feasible. Although promising …

Molecular understanding of serological immunity to influenza has been confounded by the
complexity of the polyclonal antibody response in humans. Here we used high-resolution …