Hedgehog signaling: implications in liver pathophysiology

RK Dutta, JH Jun, K Du, AM Diehl - Seminars in Liver Disease, 2023 - thieme-connect.com
The purpose of this review is to summarize current knowledge about the role of the
Hedgehog signaling pathway in liver homeostasis and disease. Hedgehog is a …

[HTML][HTML] Hepatocyte smoothened activity controls susceptibility to insulin resistance and nonalcoholic fatty liver disease

T Chen, G Dalton, SH Oh, R Maeso-Diaz, K Du… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis,
strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state …

Heterogeneity of foam cell biogenesis across diseases

V Guerrini, B Prideaux, R Khan, S Subbian, Y Wang… - bioRxiv, 2023 - biorxiv.org
Foam cells are dysfunctional, lipid-laden macrophages associated with chronic inflammation
of infectious and non-infectious origin. For decades, the paradigm underlying foam cell …

[HTML][HTML] NR1H3基因调控猪前体脂肪细胞分化的研究

史明月, 张雪莲, 杨晓奋, 牛瑾, 邢建东, 路畅, 高鹏飞… - 畜牧兽医学报, 2022 - html.rhhz.net
旨在探讨NR1H3 基因在猪脂肪组织中的发育性表达规律及对猪前体脂肪细胞成脂分化的影响,
以确定其在脂肪沉积过程中的主要功能. 本研究采用qRT-PCR 方法检测30, 90,240 …