Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
Strategies for 3D bioprinting of spheroids: A comprehensive review
Biofabricated tissues have found numerous applications in tissue engineering and
regenerative medicine in addition to the promotion of disease modeling and drug …
regenerative medicine in addition to the promotion of disease modeling and drug …
Advances in Spheroids and Organoids on a Chip
Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …
medicine and drug screening. They replicate the structural and functional characteristics of …
The ECM: to scaffold, or not to scaffold, that is the question
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …
Open microfluidic capillary systems
E Berthier, AM Dostie, UN Lee, J Berthier… - Analytical …, 2019 - ACS Publications
Open microfluidic capillary systems are a rapidly evolving branch of microfluidics where
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …
Spheroid engineering in microfluidic devices
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …
biophysical and biochemical cellular responses. However, these culture methods, having …
[HTML][HTML] The impact of microfluidics in high-throughput drug-screening applications
P De Stefano, E Bianchi, G Dubini - Biomicrofluidics, 2022 - pubs.aip.org
Drug discovery is an expensive and lengthy process. Among the different phases, drug
discovery and preclinical trials play an important role as only 5–10 of all drugs that begin …
discovery and preclinical trials play an important role as only 5–10 of all drugs that begin …
Facile one step formation and screening of tumor spheroids using droplet‐microarray platform
Tumor spheroids or microtumors are important 3D in vitro tumor models that closely
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …
resemble a tumor's in vivo “microenvironment” compared to 2D cell culture. Microtumors are …
Integrating spheroid‐on‐a‐chip with tubeless rocker platform: A high‐throughput biological screening platform
Spheroid‐on‐a‐chip platforms are emerging as promising in vitro models that enable
screening of the efficacy of biologically active ingredients. Generally, the supply of liquids to …
screening of the efficacy of biologically active ingredients. Generally, the supply of liquids to …
A microfluidic multisize spheroid array for multiparametric screening of anticancer drugs and blood–brain barrier transport properties
Physiological‐relevant in vitro tissue models with their promise of better predictability have
the potential to improve drug screening outcomes in preclinical studies. Despite the …
the potential to improve drug screening outcomes in preclinical studies. Despite the …