The first member and eponym of the rhodopsin family was identified in the 1930s as the
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in
transmembrane signaling. Their involvement in many physiological processes makes them …

G-protein coupled receptors (GPCRs) constitute the largest class of membrane proteins and
are a major drug target. A serious obstacle to studying GPCR structure/function …

α-Helical membrane proteins have eluded investigation of their thermodynamic stability in
lipid bilayers. Reversible denaturation curves have enabled some headway in determining …

Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane
proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have …

Retinal-binding proteins, mainly known as rhodopsins, function as photosensors and ion
transporters in a wide range of organisms. From halobacterial light-driven proton pump …

Haloarchaea are known for its adaptation in extreme saline environment. Halophilic archaea
produces carotenoid pigments and proton pumps to protect them from extremes of salinity …

KCNQ1 (also known as KV7. 1 or KVLQT1) is a voltage-gated potassium channel modulated
by members of the KCNE protein family. Among multiple functions, KCNQ1 plays a critical …

Single amino acid mutations provide quantitative insight into the energetics that underlie the
dynamics and folding of membrane proteins. Chemical denaturation is the most widely used …

While interactions of single-span transmembrane helices have been studied to a significant
extent in the past years, the folding of polytopic α-helical transmembrane proteins, as well as …