Deep brain stimulation in neurological diseases and experimental models: from molecule to complex behavior

P Gubellini, P Salin, L Kerkerian-Le Goff… - Progress in …, 2009 - Elsevier
Deep brain stimulation (DBS) has proven to be capable of providing significant benefits for
several neuropathologies. It is highly effective in reducing the motor symptoms of …

Current directions in deep brain stimulation for Parkinson's disease—directing current to maximize clinical benefit

A Merola, A Romagnolo, V Krishna, S Pallavaram… - Neurology and …, 2020 - Springer
Several single-center studies and one large multicenter clinical trial demonstrated that
directional deep brain stimulation (DBS) could optimize the volume of tissue activated (VTA) …

Modeling of a segmented electrode for desynchronizing deep brain stimulation

J Buhlmann, L Hofmann, PA Tass… - Frontiers in …, 2011 - frontiersin.org
Deep brain stimulation (DBS) is an effective therapy for medically refractory movement
disorders like Parkinson's disease. The electrodes, implanted in the target area within the …

Variation in deep brain stimulation electrode impedance over years following electrode implantation

D Satzer, D Lanctin, LE Eberly, A Abosch - Stereotactic and functional …, 2014 - karger.com
Background: Deep brain stimulation (DBS) electrode impedance is a major determinant of
current delivery to target tissues, but long-term variation in impedance has received little …

Stereotactic implantation of deep brain stimulation electrodes: a review of technical systems, methods and emerging tools

S Hemm, K Wårdell - Medical & biological engineering & computing, 2010 - Springer
Deep brain stimulation (DBS) has become increasingly important for the treatment and relief
of neurological disorders such as Parkinson's disease, tremor, dystonia and psychiatric …

Refining the deep brain stimulation target within the limbic globus pallidus internus for Tourette syndrome

L Akbarian-Tefaghi, H Akram, J Johansson… - Stereotactic and …, 2017 - karger.com
Background: Deep brain stimulation (DBS) in patients with severe, refractory Tourette
syndrome (TS) has demonstrated promising but variable results thus far. The thalamus and …

Multi-objective particle swarm optimization for postoperative deep brain stimulation targeting of subthalamic nucleus pathways

E Peña, S Zhang, R Patriat, JE Aman… - Journal of neural …, 2018 - iopscience.iop.org
Objective. The effectiveness of deep brain stimulation (DBS) therapy strongly depends on
precise surgical targeting of intracranial leads and on clinical optimization of stimulation …

Deep brain stimulation programming strategies: segmented leads, independent current sources, and future technology

B Patel, S Chiu, JK Wong, A Patterson… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Advances in neuromodulation and deep brain stimulation (DBS) technologies
have facilitated opportunities for improved clinical benefit and side effect management …

Understanding the effects and adverse reactions of deep brain stimulation: is it time for a paradigm shift toward a focus on heterogenous biophysical tissue properties …

C Ineichen, NR Shepherd, O Sürücü - Frontiers in human …, 2018 - frontiersin.org
Deep brain stimulation (DBS) has been proven to be an effective treatment modality for
various late-stage neurological and psychiatric disorders. However, knowledge on the …

The influence of reactivity of the electrode–brain interface on the crossing electric current in therapeutic deep brain stimulation

N Yousif, R Bayford, X Liu - Neuroscience, 2008 - Elsevier
The use of deep brain stimulation (DBS) as an effective clinical therapy for a number of
neurological disorders has been greatly hindered by the lack of understanding of the …