The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …

The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …

Abstract p53 is a transcription factor that suppresses tumor growth through regulation of
dozens of target genes with diverse biological functions. The activity of this master …

Significance: This review highlights the critical role of transforming growth factor beta (TGF-
β) 1–3 within different phases of wound healing, in particular, late-stage wound healing. It is …

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

Yes-associated protein (YAP), the central mediator of Hippo pathway, not only regulates a
diversity of cellular processes during development but also plays a pivotal role in …