Pharmacological targeting of the cancer epigenome
Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …
disease initiation, maintenance and therapy resistance. As a result, there have been …
Small-molecule tools for YEATS domain proteins
MA Erb - Current Opinion in Chemical Biology, 2023 - Elsevier
Chromatin reader domains are protein folds that bind to post-translational modifications of
histones and other chromatin-associated proteins. Compared to other families of reader …
histones and other chromatin-associated proteins. Compared to other families of reader …
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression
The histone acylation reader eleven-nineteen leukemia (ENL) plays a pivotal role in
sustaining oncogenesis in acute leukemias, particularly in mixed-lineage leukemia …
sustaining oncogenesis in acute leukemias, particularly in mixed-lineage leukemia …
Structural studies of intrinsically disordered MLL‐fusion protein AF9 in complex with peptidomimetic inhibitors
Y Yang, E Ahmad, V Premkumar, A Liu… - Protein …, 2024 - Wiley Online Library
Abstract AF9 (MLLT3) and its paralog ENL (MLLT1) are members of the YEATS family of
proteins with important role in transcriptional and epigenetic regulatory complexes. These …
proteins with important role in transcriptional and epigenetic regulatory complexes. These …
Unveiling the role of GAS41 in cancer progression
K Ji, L Li, H Liu, Y Shen, J Jiang, M Zhang… - Cancer Cell …, 2023 - Springer
GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer
development. It serves as a highly promising epigenetic reader, facilitating precise …
development. It serves as a highly promising epigenetic reader, facilitating precise …
[HTML][HTML] The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia
H Hu, AG Muntean - Experimental Hematology, 2023 - Elsevier
Recent studies have uncovered similarities and differences between 2 highly homologous
epigenetic reading proteins, namely, ENL (MLLT1) and AF9 (MLLT3) with therapeutic …
epigenetic reading proteins, namely, ENL (MLLT1) and AF9 (MLLT3) with therapeutic …
MLLT1 超伸长复合亚基在肝细胞癌发生发展中的作用及其临床意义
于华婧， 魏路阳， 刘姗姗， 管成剑， 张忠涛 - 解剖学报, 2023 - jpxb.bjmu.edu.cn
目的探讨MLLT1 超伸长复合亚基(MLLT1) 在肝细胞癌发生中的作用以及其对肝细胞癌免疫微
环境的影响. 方法利用多因素Cox 回归分析以及GEPIA, UALCAN 等肿瘤基因分析工具 …
环境的影响. 方法利用多因素Cox 回归分析以及GEPIA, UALCAN 等肿瘤基因分析工具 …
The Role of the YEATS Epigenetic Reader in MLL-r Fusion Proteins
HY Hu - 2023 - deepblue.lib.umich.edu
MLL (KMT2a) translocations are found in~ 10% of acute leukemia patients, giving rise to an
aggressive subset of leukemias. The majority of MLL fusion partners are members of …
aggressive subset of leukemias. The majority of MLL fusion partners are members of …
Role and clinical significance of MLLT1 super elongation complex subunit in the occurrence and development of hepatocellular carcinoma
YUHWEI Lu-yang, LIUSG Cheng-jian… - Acta Anatomica …, 2023 - jpxb.bjmu.edu.cn
Objective To investigate the role of MLLT1 in hepatocellular carcinoma (HCC) and its impact
on the tumor immune microenvironment. Methods Multivariate Cox regression analysis and …
on the tumor immune microenvironment. Methods Multivariate Cox regression analysis and …