In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

Membrane proteins present a challenge for structural biology. In this article, we review some
of the recent developments that advance the application of NMR to membrane proteins, with …

In this chapter, we summarize the isotopic labeling strategies used to obtain high-quality
solution and solid-state NMR spectra of biological samples, with emphasis on integral …

Unlike water soluble proteins, the structures of helicaltransmembrane proteins depend on a
very complex environment. These proteins sit in the midst of dramatic electrical and …

Many biological membranes consist of 50% or more (by weight) membrane proteins, which
constitute approximately one-third of all proteins expressed in biological organisms. Helical …

We used oriented solid-state NMR spectroscopy and biochemical cross-linking experiments
to demonstrate that the ligand-free membrane protein transporter EmrE forms anti-parallel …

EmrE is a multidrug resistance efflux pump with specificity to a wide range of antibiotics and
antiseptics. To obtain atomic-scale insight into the attributes of the native state that encodes …

Membrane proteins have always presented technical challenges for structural studies
because of their requirement for a lipid environment. Multiple approaches exist including X …

Oriented-sample solid-state NMR represents one of few experimental methods capable of
characterising the membrane-bound conformation of proteins in the cell membrane. Since …