Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

[HTML][HTML] Prevalence of knee osteoarthritis features on magnetic resonance imaging in asymptomatic uninjured adults: a systematic review and meta-analysis

AG Culvenor, BE Øiestad, HF Hart… - British journal of sports …, 2019 - bjsm.bmj.com
Background Knee MRI is increasingly used to inform clinical management. Features
associated with osteoarthritis are often present in asymptomatic uninjured knees; however …

Effect of intra-articular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis: the RESTORE …

KL Bennell, KL Paterson, BR Metcalf, V Duong, J Eyles… - Jama, 2021 - jamanetwork.com
Importance Most clinical guidelines do not recommend platelet-rich plasma (PRP) for knee
osteoarthritis (OA) because of lack of high-quality evidence on efficacy for symptoms and …

An algorithmic approach to reducing unexplained pain disparities in underserved populations

E Pierson, DM Cutler, J Leskovec, S Mullainathan… - Nature Medicine, 2021 - nature.com
Underserved populations experience higher levels of pain. These disparities persist even
after controlling for the objective severity of diseases like osteoarthritis, as graded by human …

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial

J Freitag, D Bates, J Wickham, K Shah… - Regenerative …, 2019 - Taylor & Francis
Aim: To evaluate the efficacy of autologous adipose-derived mesenchymal stem cell
(ADMSC) therapy on pain, function and disease modification in knee osteoarthritis. Methods …

[HTML][HTML] Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review

P Dainese, KV Wyngaert, S De Mits, R Wittoek… - Osteoarthritis and …, 2022 - Elsevier
Objective To systematically review the literature on the relationship between markers of
inflammation and pain in patients with knee osteoarthritis (OA). Methods We searched …

Epidemiology of OA

T Neogi, Y Zhang - Rheumatic diseases clinics of North …, 2012 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis in the US, and a leading cause of
disability. It is typically defined in epidemiologic studies on the basis of radiographic findings …

Deep convolutional neural network for segmentation of knee joint anatomy

Z Zhou, G Zhao, R Kijowski, F Liu - Magnetic resonance in …, 2018 - Wiley Online Library
Purpose To describe and evaluate a new segmentation method using deep convolutional
neural network (CNN), 3D fully connected conditional random field (CRF), and 3D simplex …

Synovitis in knee osteoarthritis: a precursor of disease?

I Atukorala, CK Kwoh, A Guermazi… - Annals of the …, 2016 - ard.bmj.com
Objectives It is unknown whether joint inflammation precedes other articular tissue damage
in osteoarthritis. Therefore, this study aims to determine if synovitis precedes the …

[HTML][HTML] Osteoarthritis year in review 2023: biomechanics

LE Diamond, T Grant, SD Uhlrich - Osteoarthritis and cartilage, 2024 - Elsevier
Biomechanics plays a significant yet complex role in osteoarthritis (OA) onset and
progression. Identifying alterations in biomechanical factors and their complex interactions is …