Oligonucleotides have many important applications, including as primers in polymerase
chain reactions and probes for DNA sequencing. They are proposed as a diagnostic and …

The last few years have seen a rise in the identification and development of bio-therapeutics
through the use of cutting-edge delivery methods or bio-formulations, which has created bio …

A label-free method for determining the 5′-end cap identity and orientation of a messenger
RNA (mRNA) is described. Biotin-tagged probes that were complementary to the 5′ end of …

Eluforsen (previously known as QR-010) is a 33-mer 2′-O-methyl modified
phosphorothioate antisense oligonucleotide targeting the F508del mutation in the gene …

Since 2016, eight new oligonucleotide therapies have been approved which has led to
increased interest in oligonucleotide analysis. There is a particular need for powerful …

The chemical composition of the solution has a critical impact on the electrospray desorption
efficiency of oligonucleotides. Several physiochemical properties of various organic …

Antisense oligonucleotides have been successfully investigated for the treatment of different
types of diseases. Detection and determination of antisense oligonucleotides and their …

Recent findings have elucidated numerous novel biological functions for oligonucleotides.
Current standard methods for the study of oligonucleotides (ie, hybridization and PCR) are …

Antisense oligonucleotides (ASOs) have been touted as an emerging therapeutic class to
treat genetic disorders and infections. The evaluation of metabolic stability of ASOs during …

Magnetic nanoparticles coated with zwitterionic poly (ionic liquid) s were applied for
dispersive solid-phase extraction of oligonucleotides. The materials were synthesized by …