Synaptic vesicle glycoprotein 2A: features and functions

R Rossi, S Arjmand, SL Bærentzen, A Gjedde… - Frontiers in …, 2022 - frontiersin.org
In recent years, the field of neuroimaging dramatically moved forward by means of the
expeditious development of specific radioligands of novel targets. Among these targets, the …

Imaging of synaptic density in neurodegenerative disorders

RE Carson, M Naganawa, T Toyonaga… - Journal of Nuclear …, 2022 - Soc Nuclear Med
PET technology has produced many radiopharmaceuticals that target specific brain proteins
and other measures of brain function. Recently, a new approach has emerged to image …

Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease

D Bertoglio, J Bard, M Hessmann, L Liu… - Science translational …, 2022 - science.org
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathologic …

Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression

RH Asch, CG Abdallah, RE Carson… - …, 2024 - nature.com
The development of novel radiotracers for Positron Emission Tomography (PET) imaging
agents targeting the synaptic vesicle glycoprotein 2 A (SV2A), an integral glycoprotein …

[HTML][HTML] Toward functional PET imaging of the spinal cord

P Courault, L Zimmer, S Lancelot - Seminars in Nuclear Medicine, 2024 - Elsevier
At present, spinal cord imaging primarily uses magnetic resonance imaging (MRI) or
computed tomography (CT), but the greater sensitivity of positron emission tomography …

Changes in brain activity with tominersen in early-manifest Huntington's disease

DJ Hawellek, P Garces, AH Meghdadi… - Brain …, 2022 - academic.oup.com
It is unknown whether alterations in EEG brain activity caused by Huntington's disease may
be responsive to huntingtin-lowering treatment. We analysed EEG recordings of 46 patients …

PET imaging of synaptic density: challenges and opportunities of synaptic vesicle glycoprotein 2A PET in small animal imaging

T Toyonaga, A Fesharaki-Zadeh… - Frontiers in …, 2022 - frontiersin.org
The development of novel PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A)
allowed for the in vivo detection of synaptic density changes, which are correlated with the …

Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab) Normal Neurodevelopment in Humans and Rodents

C Millevert, N Vidas-Guscic, L Vanherp… - Journal of …, 2023 - Soc Neuroscience
Neurodevelopmental disorders (NDDs) are a group of complex neurologic and psychiatric
disorders. Functional and molecular imaging techniques, such as resting-state functional …

SV2A PET imaging is a noninvasive marker for the detection of spinal damage in experimental models of spinal cord injury

D Bertoglio, N Halloin, S De Lombaerde… - Journal of nuclear …, 2022 - Soc Nuclear Med
Traumatic spinal cord injury (SCI) is a neurologic condition characterized by long-term motor
and sensory neurologic deficits as a consequence of an external physical impact damaging …

Positron emission tomography (PET) imaging biomarkers in Huntington's disease

L Everix, S Staelens, D Bertoglio - Biomarkers for Huntington's Disease …, 2023 - Springer
Huntington's disease (HD) is a rare, autosomal, and dominantly inherited
neurodegenerative disease characterized by aggregation of mutated Huntingtin protein …