CXCL6: A potential therapeutic target for inflammation and cancer

CL Dai, HX Yang, QP Liu, K Rahman… - Clinical and Experimental …, 2023 - Springer
Chemokines were originally defined as cytokines that affect the movement of immune cells.
In recent years, due to the increasing importance of immune cells in the tumor …

CXCL16 deficiency attenuates renal injury and fibrosis in salt-sensitive hypertension

H Liang, Z Ma, H Peng, L He, Z Hu, Y Wang - Scientific reports, 2016 - nature.com
Inflammation plays an important role in the pathogenesis of hypertensive kidney disease.
However, the molecular mechanisms underlying the induction of inflammation are not …

Circ_0000524/miR‐500a‐5p/CXCL16 axis promotes podocyte apoptosis in membranous nephropathy

Z Sun, Q Xu, Y Ma, S Yang, J Shi - European Journal of Clinical …, 2021 - Wiley Online Library
Background Podocytes apoptosis is a hallmark of membranous nephropathy (MN).
Circ_0000524 has been reported to be associated with patients with MN, whereas the effect …

MiR‐145‐5p inhibits proliferation and inflammatory responses of RMC through regulating AKT/GSK pathway by targeting CXCL16

J Wu, Y He, Y Luo, L Zhang, H Lin, X Liu… - Journal of Cellular …, 2018 - Wiley Online Library
The main pathological characteristics of chronic glomerulonephritis (CGN) are diffuse
mesangial cells proliferation and inflammatory responses. Our previous studies have …

Epoxyeicosatrienoic acid analog EET-A blunts development of lupus nephritis in mice

MA Hye Khan, A Stavniichuk, MA Sattar… - Frontiers in …, 2019 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that
causes life threatening renal disease and current therapies are limited with serious side …

Enoxaparin prevents CXCL16/ADAM10-mediated cisplatin renal toxicity: Role of the coagulation system and the transcriptional factor NF-κB

AM Aboyoussef, AR Abdel-Sattar, MS Abdel-Bakky… - Life Sciences, 2021 - Elsevier
Background and aims CXC ligand 16 (CXCL16) is an exceptional chemokine that is
expressed as transmembrane and soluble forms. Our aim is to shed lights on the role of …

[HTML][HTML] Pediatric chronic kidney disease: blood cell count indexes as inflammation markers

AJ Silva, AC Santos Lopes, APL Mota… - Brazilian Journal of …, 2023 - SciELO Brasil
Introduction: Chronic kidney disease (CKD) is defined as a progressive decline of kidney
functions. In childhood, the main triggering factors are congenital anomalies of the kidneys …

The perioperative time course and clinical significance of the chemokine CXCL 16 in patients undergoing cardiac surgery

D Dreymueller, A Goetzenich… - Journal of Cellular …, 2016 - Wiley Online Library
The chemokine CXCL 16 and its receptor CXCR 6 have been linked to the pathogenesis of
acute and chronic cardiovascular disease. However, data on the clinical significance of …

Resistance of mice to Leptospira infection and correlation with chemokine response

RH Domingos, EB Pavanel, E Nakajima… - Immunobiology, 2017 - Elsevier
Leptospirosis is globally widespread neglected disease, affecting most mammalian species.
Clinical signs can be confused with other diseases which make the diagnosis and treatment …

Qinggan Huoxue recipe protects against experimental alcoholic Liver fibrosis through CXCL16 inhibition

L Tang, X Yu, L Zou, S Li, Y Cheng… - Evidence‐Based …, 2023 - Wiley Online Library
Background. Qinggan Huoxue recipe (QGHXR), a traditional Chinese medicinal formula,
has a protective effect against liver fibrosis. However, the underlying mechanisms remain …