[HTML][HTML] Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies
Y Jiang, LT MacNeil - Molecular Neurodegeneration, 2023 - Springer
The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …
related tauopathies highlights the need for a more comprehensive understanding of the …
Scalable approaches for functional analyses of whole-genome sequencing non-coding variants
Non-coding genetic variants outside of protein-coding genome regions play an important
role in genetic and epigenetic regulation. It has become increasingly important to …
role in genetic and epigenetic regulation. It has become increasingly important to …
[HTML][HTML] Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system
V Fominykh, AA Shadrin, PP Jaholkowski… - Neurobiology of …, 2023 - Elsevier
Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease
(AD), including immune-linked genetic variants and molecular pathways, microglia and …
(AD), including immune-linked genetic variants and molecular pathways, microglia and …
[HTML][HTML] An integrated toolkit for human microglia functional genomics
I Haq, JC Ngo, N Roy, RL Pan, N Nawsheen… - Stem Cell Research & …, 2024 - Springer
Background Microglia, the brain's resident immune cells, play vital roles in brain
development, and disorders like Alzheimer's disease (AD). Human iPSC-derived microglia …
development, and disorders like Alzheimer's disease (AD). Human iPSC-derived microglia …
[HTML][HTML] The broken Alzheimer's disease genome
The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant
challenges to therapeutic and preventative interventions. Despite these difficulties …
challenges to therapeutic and preventative interventions. Despite these difficulties …
Alzheimer DataLENS: An open data analytics portal for Alzheimer's disease research
Background: Recent Alzheimer's disease (AD) discoveries are increasingly based on
studies from a variety of omics technologies on large cohorts. Currently, there is no easily …
studies from a variety of omics technologies on large cohorts. Currently, there is no easily …
[HTML][HTML] Cross-phenotype associations between Alzheimer's Disease and its comorbidities may provide clues to progression
A Moore, MD Ritchie - AMIA Summits on Translational Science …, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, with
one in nine people over the age of 65 living with the disease in 2023. In this study, we used …
one in nine people over the age of 65 living with the disease in 2023. In this study, we used …
Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes
Genome-wide association studies of late-onset Alzheimer's disease (AD) have highlighted
the importance of variants associated with genes expressed by the innate immune system in …
the importance of variants associated with genes expressed by the innate immune system in …
NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research
A Kuzma, O Valladares, E Greenfest-Allen, H Nicaretta… - medRxiv, 2024 - medrxiv.org
NIAGADS is the National Institute on Aging (NIA) designated national data repository for
human genetics research on Alzheimers Disease and related dementia (ADRD). NIAGADS …
human genetics research on Alzheimers Disease and related dementia (ADRD). NIAGADS …
[HTML][HTML] Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes
Genome-wide association studies of late-onset Alzheimer's disease (AD) have highlighted
the importance of variants associated with genes expressed by the innate immune system in …
the importance of variants associated with genes expressed by the innate immune system in …