Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …

Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

The past decade has brought great strides in our understanding of adaptive immunity in
neonatal mice. Although poor immune responses are commonly observed, it is now clear …

During early post-natal life, neonates must adjust to the transition from the sheltered intra-
uterine environment to the microbe-laden external world, wherein they encounter a …

The immune system of infants is actively downregulated during pregnancy and therefore the
first months of life represent a period of heightened susceptibility to infection. After birth …

Aims/hypothesis Seroconversion to islet autoantibodies precedes type 1 diabetes. This
study aimed to identify periods of high seroconversion incidence, which could be targeted …

Villitis of unknown etiology (VUE) is an important pattern of placental injury occurring
predominantly in term placentas. Although overlapping with infectious villitis, its clinical and …

Dendritic cells (DCs) are leukocytes that are emerging as chief orchestrators of immune
responses. The crucial task of DCs is the continuous surveillance of antigen-exposed sites …

Background Early-life human rhinovirus infection has been linked to asthma development in
high-risk infants and children. Nevertheless, the role of rhinovirus infection in the initiation of …

BACKGROUND: Exposure to furred pets might confer protection against the development of
allergic sensitization through a mechanism that is incompletely understood. OBJECTIVE …