Adrenomedullin (ADM) is a peptide hormone first discovered in 1993 in pheochromocytoma.
It is synthesized by endothelial and vascular smooth muscle cells and diffuses freely …

Heart failure (HF) biomarkers have dramatically impacted the way HF patients are evaluated
and managed. B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are the …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

Objectives: Our purpose was to assess the diagnostic utility of mid-regional pro–atrial
natriuretic peptide (MR-proANP) for the diagnosis of acute heart failure (AHF) and the …

This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Since the discovery of adrenomedullin in 1993 several hundred papers have been
published regarding the regulation of its secretion and the multiplicity of its actions. It has …

The heart is a highly structured organ consisting of different cell types, including myocytes,
endothelial cells, fibroblasts, stem cells, and inflammatory cells. This pluricellularity provides …

Cardiovascular disease (CVD) is a leading cause of death worldwide and continues to
increase in prevalence compared to previous decades, in part because of the aging of the …

Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction
are at a high risk of developing heart failure. The addition of neprilysin inhibition to renin …

The volume of extracellular fluid (ECF) is maintained within narrow limits in normal human
subjects, despite day-to-day variations in dietary intake of salt and water over a wide range …