The thymus is a crucial organ for the development of T cells. T cell progenitors first migrate
from the bone marrow into the thymus. During the journey to become a mature T cell …

The thymus is unique in its ability to support the maturation of phenotypically and
functionally distinct T cell sub-lineages. Through its combined production of MHC-restricted …

Neutrophil recruitment into the joint is a hallmark of inflammatory arthritides, including
rheumatoid arthritis (RA). In a mouse model of autoantibody-induced inflammatory arthritis …

Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has
long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with …

Background γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR),
mediate cancer immune surveillance by sensing early metabolic changes in malignant …

Abstract Ethnopharmacological relevance Colla Corii Asini is a widely used traditional
Chinese medicine to treat anemia with a long history due to its stimulating effect in …

Simple Summary While radiotherapy remains a key therapy for many cancers, in recent
years, DNA repair inhibitors, particularly PARP inhibitors, and immunotherapy, specifically …

Hematopoietic stem and progenitor cells (HSPCs) egress from bone marrow (BM) during
homeostasis and at increased rates during stress; however, the mechanisms regulating their …

Although thymic involution has been linked to the increased testosterone in males after
puberty, its detailed mechanism and clinical application related to T-cell reconstitution in …

The recruitment of lymphoid progenitors to the thymus is essential to sustain T cell
production throughout life. Importantly, it also limits T lineage regeneration following bone …