Traditionally, selected plant sources have been explored for medicines to treat convulsions.
This continues today, especially in countries with low-income rates and poor medical …

Rare genetic diseases are a group of pathologies with often unmet clinical needs. Even if
rare by a single genetic disease (from 1/2000 to 1/more than 1,000,000), the total number of …

Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent
seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts …

Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the
duration and extent of neuronal excitation by removing glutamate from the synaptic cleft …

(R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure
models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and …

Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …

Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …

Epilepsy is a common disorder of the brain characterized by spontaneous recurrent
seizures, which develop gradually during a process called epileptogenesis. The mechanistic …

Over the past decades the zebrafish has emerged as an excellent model organism with
which to study the biology of all glial cell types in nervous system development, plasticity …

Zebrafish (Danio rerio) has been successfully used for decades in developmental studies
and disease modelling. The remarkable uptake of zebrafish as a model system is partly due …