Recent advancement in mRNA vaccine development and applications

N Al Fayez, MS Nassar, AA Alshehri, MK Alnefaie… - Pharmaceutics, 2023 - mdpi.com
Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications
has evolved rapidly over the last decade. The mRVNA vaccine has proven therapeutic …

mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer

RR Malla, M Srilatha, B Farran, GP Nagaraju - Molecular Therapy, 2024 - cell.com
mRNA vaccines have evolved as promising cancer therapies. These vaccines can encode
tumor-allied antigens, thus enabling personalized treatment approaches. They can also …

Extracellular vesicles and exosomes: novel insights and perspectives on lung cancer from early detection to targeted treatment

S Rahimian, H Najafi, B Afzali, M Doroudian - Biomedicines, 2024 - mdpi.com
Lung cancer demands innovative approaches for early detection and targeted treatment. In
addressing this urgent need, exosomes play a pivotal role in revolutionizing both the early …

[HTML][HTML] Enhancing siRNA cancer therapy: Multifaceted strategies with lipid and polymer-based carrier systems

NK Dastgerdi, NK Dastgerdi, H Bayraktutan… - International Journal of …, 2024 - Elsevier
Cancers are increasing in prevalence and many challenges remain for their treatment, such
as chemoresistance and toxicity. In this context, siRNA-based therapeutics have many …

Harnessing nanovaccines for effective immunization─ a special concern on COVID-19: facts, fidelity, and future prospective

AD Gholap, J Gupta, P Kamandar… - ACS biomaterials …, 2023 - ACS Publications
Nanotechnology has emerged as a transformative pathway in vaccine research and
delivery. Nanovaccines, encompassing lipid and nonlipid formulations, exhibit considerable …

Glucosamine-modified mesoporous silica-coated magnetic nanoparticles: a “Raisin-Cake”-like structure as an efficient theranostic platform for targeted methotrexate …

F Farjadian, Z Faghih, M Fakhimi, P Iranpour… - Pharmaceutics, 2023 - mdpi.com
This study presents the synthesis of glucosamine-modified mesoporous silica-coated
magnetic nanoparticles (MNPs) as a therapeutic platform for the delivery of an anticancer …

Expanding CAR-T cell immunotherapy horizons through microfluidics

H Kim, S Kim, H Lim, AJ Chung - Lab on a Chip, 2024 - pubs.rsc.org
Chimeric antigen receptor (CAR)-T cell therapies have revolutionized cancer treatment,
particularly in hematological malignancies. However, their application to solid tumors is …

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

[HTML][HTML] Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery

MA Haque, A Shrestha, CM Mikelis… - International Journal of …, 2024 - Elsevier
Nucleic acid-based therapeutics are a common approach that is increasingly popular for a
wide spectrum of diseases. Lipid nanoparticles (LNPs) are promising delivery carriers that …

Viral Nanoparticles‐Mediated Delivery of Therapeutic Cargo

S Zanganeh, M Doroudian, ZR Nowzari… - Advanced …, 2023 - Wiley Online Library
The rapid advancement of nanotechnology in recent years has opened new avenues of
investigation for biomedical sciences. Viral nanoparticles (VNPs) are formulated from plant …