Cyclodextrins, from molecules to applications

G Crini, S Fourmentin, É Fenyvesi, G Torri… - Environmental chemistry …, 2018 - Springer
Cyclodextrins are among the most remarkable macrocyclic molecules with significant
theoretical and practical impacts in chemistry and biology. Cyclodextrins belong to the family …

Cyclodextrins, natural compounds, and plant bioactives—a nutritional perspective

S Wüpper, K Lüersen, G Rimbach - Biomolecules, 2021 - mdpi.com
Cyclodextrins (CDs) are a group of cyclic oligosaccharides produced from starch or starch
derivatives. They contain six (αCD), seven (βCD), eight (γCD), or more glucopyranose …

Lysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives

M Solomon, S Muro - Advanced drug delivery reviews, 2017 - Elsevier
Lysosomes and lysosomal enzymes play a central role in numerous cellular processes,
including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies …

Affinity-driven design of cargo-switching nanoparticles to leverage a cholesterol-rich microenvironment for atherosclerosis therapy

H Kim, S Kumar, DW Kang, H Jo, JH Park - ACS nano, 2020 - ACS Publications
Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are
not only the main components of the plaques but also key inflammation-triggering sources …

Autosomal recessive cerebellar ataxias: paving the way toward targeted molecular therapies

M Synofzik, H Puccio, F Mochel, L Schöls - Neuron, 2019 - cell.com
Autosomal-recessive cerebellar ataxias (ARCAs) comprise a heterogeneous group of rare
degenerative and metabolic genetic diseases that share the hallmark of progressive …

Cyclodextrins as emerging therapeutic tools in the treatment of cholesterol-associated vascular and neurodegenerative diseases

C Coisne, S Tilloy, E Monflier, D Wils, L Fenart… - Molecules, 2016 - mdpi.com
Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting
the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism …

Cyclodextrins applied to the treatment of lysosomal storage disorders

Y Ishitsuka, T Irie, M Matsuo - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …

CAR Macrophages: a promising novel immunotherapy for solid tumors and beyond

J Lu, Y Ma, Q Li, Y Xu, Y Xue, S Xu - Biomarker Research, 2024 - Springer
With the advent of adoptive cellular therapy, chimeric antigen receptor (CAR)-T cell therapy
has gained widespread application in cancer treatment and has demonstrated significant …

Cyclodextrins: Only pharmaceutical excipients or full-fledged drug candidates?

T Kovacs, P Nagy, G Panyi, L Szente, Z Varga… - Pharmaceutics, 2022 - mdpi.com
Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive
pharmaceutical applications due to their unique truncated cone-shaped structure with a …

Cyclodextrins and iatrogenic hearing loss: new drugs with significant risk

MA Crumling, KA King, RK Duncan - Frontiers in cellular …, 2017 - frontiersin.org
Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine,
industry and basic sciences owing to their ability to solubilize and stabilize guest …