Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Chronic stress is an emotional experience that occurs when people encounter something
they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases …

Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of
cancer-related death worldwide. Neurotransmitter-initiated signalling pathway is profoundly …

ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early
activation of the integrated stress response. Its promising safety profile and broad-spectrum …

Purpose: Temozolomide resistance remains a major obstacle in the treatment of
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …

Background Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a
specific subpopulation of cells necessary for cancer initiation and metastasis; however, the …

The dopamine D2 receptor (D2R) family is upregulated in many cancers and tied to
stemness. Reduced cancer risk has been correlated with disorders such as schizophrenia …

Background ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the
blood–brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and …

Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor.
Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown …