Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Antibiotic resistance has been highlighted by international organizations, including World
Health Organization, World Bank and United Nations, as one of the most relevant global …

Polymyxins are a last-line therapy against multidrug-resistant Pseudomonas aeruginosa;
however, resistance to polymyxins has been increasingly reported. Therefore …

Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

Genome-scale models of metabolism (GEMs) are key computational tools for the systems-
level study of metabolic networks. Here, we describe the" GEM life cycle," which we …

In this study, two susceptible strains and two multi-drug resistant clinical Escherichia coli
strains were obtained by Kirby-Bauer method, and then a GC–MS-based metabolomics …

Over the past few decades, antimicrobial resistance (AMR) has emerged as an important
threat to public health, resulting from the global propagation of multidrug-resistant strains of …

Pseudomonas aeruginosa is one of the leading causes of hospital-acquired infections. To
decipher the metabolic mechanisms associated with virulence and antibiotic resistance, we …

Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large
number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant …

A genome-scale metabolic model (GEM) represents metabolic pathways of an organism in a
mathematical form and can be built using biochemistry and genome annotation data. GEMs …