Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Background Alzheimer's disease (AD) is the most common type of dementia, affecting one in
eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown …

The only drugs currently approved for the treatment of Alzheimer's Disease (AD) are four
acetylcholinesterase inhibitors and the NMDA antagonist memantine. Apart from these …

Early therapeutic interventions are essential to prevent Alzheimer Disease (AD). The
association of several inflammation-related genetic markers with AD and the early activation …

We perform a large-scale meta-analysis of 51 peer-reviewed 3xTg-AD mouse publications
to compare Alzheimer's disease (AD) quantitative clinical outcome measures, including …

Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple
coneflower) plant (Echinacea purpurea), has been regarded as a nutraceutical that has …

The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …

Protein aggregation likely plays a key role in the initiation and spreading of Alzheimer's
disease pathology through the brain. Soluble aggregates of amyloid beta are believed to …

Genetic studies in late-onset Alzheimer disease (LOAD) are aimed at identifying core
disease mechanisms and providing potential biomarkers and drug candidates to improve …