The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
Intranasal drug delivery: opportunities and toxicologic challenges during drug development
LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …
increased. This review article summarises information on intranasal administration for local …
Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics
ST Proulx - Cellular and Molecular Life Sciences, 2021 - Springer
Cerebrospinal fluid (CSF) is produced by the choroid plexuses within the ventricles of the
brain and circulates through the subarachnoid space of the skull and spinal column to …
brain and circulates through the subarachnoid space of the skull and spinal column to …
Non-invasive delivery strategies for biologics
AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …
clinical and commercial success, biologics are a rapidly growing class and have become a …
Safety, efficacy, and feasibility of intranasal insulin for the treatment of mild cognitive impairment and Alzheimer disease dementia: a randomized clinical trial
Importance Insulin modulates aspects of brain function relevant to Alzheimer disease and
can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin …
can be delivered to the brain using intranasal devices. To date, the use of intranasal insulin …
The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic'system?
Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
[HTML][HTML] Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies
CP Costa, JN Moreira, JMS Lobo, AC Silva - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The management of the central nervous system (CNS) disorders is challenging, due to the
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
need of drugs to cross the blood‒brain barrier (BBB) and reach the brain. Among the …
Mechanism of intranasal drug delivery directly to the brain
Neurological diseases are becoming increasingly prominent worldwide due to rapidly aging
populations, which greatly contributes to increasing healthcare costs. The development of …
populations, which greatly contributes to increasing healthcare costs. The development of …
Progress in brain targeting drug delivery system by nasal route
AR Khan, M Liu, MW Khan, G Zhai - Journal of Controlled Release, 2017 - Elsevier
The blood–brain barrier (BBB) restricts the transport of potential therapeutic moieties to the
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …
brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the …