The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …

Iron is an essential element for biological processes. Iron homeostasis is regulated through
several mechanisms, from absorption by enterocytes to recycling by macrophages and …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …

Iron and ascorbate are vital cellular constituents in mammalian systems. The bulk-
requirement for iron is during erythropoiesis leading to the generation of hemoglobin …

Ascorbic acid (AA) is a water-soluble vitamin (C) found in all bodily organs. Most mammals
synthesize it, humans are required to eat it, but all mammals need it for healthy functioning …